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UNDATED (AP) — Patrick Mahomes threw for 318 yards and a touchdown, Harrison Butker was perfect on five field goals, and the Kansas City Chiefs overcame some red-zone woes and major mistakes that cost them two more scores to hold off the Denver Broncos 22-16. Travis Kelce had eight receptions for 136 yards and the go-ahead TD grab late in the third quarter, and Tyrann Mathieu twice picked off Broncos quarterback Drew Lock — the second with 24 seconds left to seal the win. The Chiefs clinched a playoff berth by improving to 11-1 for the second time in franchise history.

In other NFL action:

UNDATED (AP) — Alfred Morris scored a pair of third-quarter touchdowns and the New York defense shut down Russell Wilson and one of the top offenses in the league 17-12.Double-digit underdogs, the Giants (5-7) handed Seattle (8-4) its first home loss of the season, sent the NFC West race into some mayhem, and kept their spot on top of the NFC East for another week. The Giants did it with starting quarterback Daniel Jones a spectator after getting hurt last week against Cincinnati. Colt McCoy led the Giants.

—Tua Tagovailoa returned from a thumb injury that forced him to miss one game, throwing for a season-high 296 yards and a score to help the Miami Dolphins rally past Cincinnati 19-7 in a game that included five ejections and a benches-clearing confrontation. Miami ranks second in the NFL in scoring defense and has allowed 10 points in the past two weeks.

— Aaron Rodgers connected with Davante Adams on two of his three touchdown passes and reached a couple of career milestones to help Green Bay hand the Eagles a 30-16 loss, their fourth consecutive. Green Bay owned a 23-3 lead in the fourth quarter when the Eagles scored two touchdowns in a span of just over a minute. Rookie quarterback Jalen Hurts, who took over for an ineffective Carson Wentz midway through the third quarter, started it by throwing a 32-yard touchdown pass to Greg Ward on fourth-and-18. Jalen Reagor then delivered a 73-yard punt return to cut the lead to 23-16 with 6:30 left, though Jake Elliott missed the extra point.

—Cam Newton ran for two touchdowns and the New England Patriots scored two TDs on special teams in a 45-0 rout of the Los Angeles Chargers on Sunday. Newton has four games this season with multiple rushing TDs, breaking the NFL record for the most such games by a quarterback. He has 11 rushing touchdowns this season. The Patriots have won two straight and four of five to get back into playoff contention in the AFC.

—Derek Carr threw a 46-yard touchdown pass to Henry Ruggs III with 5 seconds left, lifting the Las Vegas Raiders to a wild 31-28 victory over the still-winless New York Jets on Sunday. The Jets took a 28-24 lead with 5:34 remaining on Ty Johnson’s 1-yard touchdown and the defense came up with a big fourth-down stop that appeared to end New York’s agonizing wait for its first win of the season. But New York went three-and-out with a chance to seal it, but Carr found Ruggs for the winning score.

— Baker Mayfield threw for 334 yards and four touchdowns as the Browns scored the first 17 points and held on to beat the Tennessee Titans 41-35. Cleveland has won four straight. With both chasing AFC playoff berths, the Browns looked like the team leading a division as they improved to 9-3. The Titans fell into a tie atop the AFC South, though they still have the better division record. Cleveland is second in the AFC North behind unbeaten Pittsburgh.

— Jared Goff threw for 351 yards, Darrell Henderson ran for a crucial 38-yard touchdown and the Los Angeles Rams moved into a tie for the NFC West lead with a 38-28 win over the Arizona Cardinals. The Rams have won three of four and are tied with the Seahawks, who lost to the New York Giants 17-12. The Cardinals have lost four of their past five games.

— Dan Bailey kicked a 23-yard field goal with 1:49 left in overtime that lifted the Minnesota Vikings to a 27-24 victory over Jacksonville. That sent the Jaguars to their 11th straight loss. Bailey missed two extra points and a 51-yard try with 13 seconds remaining in regulation. Harrison Smith set up Bailey’s redo with an interception at the Jacksonville 46. That was the fourth turnover of the game by the Jaguars.

— Philip Rivers threw two touchdown passes in the first half and the Indianapolis defense dominated in the second half to lead the Colts to a 26-20 victory over the Houston Texans on Sunday. The Texans had a chance to take the lead with about 90 seconds left when they had second down from the Indy 2. Deshaun Watson fumbled a low snap and Anthony Walker pounced on it to seal the win.

— The New Orleans Saints finally gave up a touchdown but the defense stood tall at the end to preserve their ninth straight victory, 21-16 over the Atlanta Falcons. The Saints also clinched a playoff berth with Chicago’s 34-30 loss to Detroit. Starting again in place of Drew Brees, Taysom Hill threw the first two touchdown passes of his career. But his fumble deep in Atlanta territory sparked a Falcons comeback. Atlanta drove 85 yards against the Saints, capped by Matt Ryan’s 10-yard touchdown pass to Russell Gage with 7:43 remaining.

— Matthew Stafford threw for 402 yards and three touchdowns and Adrian Peterson scored from the 5 after Romeo Okwara strip-sacked Mitchell Trubisky with about two minutes left. The Detroit Lions won their first game under interim coach Darrell Bevell, rallying to beat the struggling Chicago Bears 34-30 on Sunday.