In 1a, Carlyle fell at home to visiting Gibault 6-0, North Clay pulled away midway through the game to beat Casey Westfield and won at home 8-1.
- Cumberland 4 WSS 3 at Altamont
- Gibault 6 Carlyle 0 at Carlyle
- Goreville 10 Galatia 0 at Cobden
- NCOE 4 Crab Orchard 1 at Gallatin County
- North Clay 8 Casey 1 at Louisville
- Arthur 19 Neoga 7 at Neoga
- New Athens 8 Maryville Christian 7 at New Athens
- Edwards County 6 Trico 1 at Steeleville
- Okaw Valley 3 Tuscola 0 at Tuscola
- Sparta 3 Waltonville 0 at Wayne City
In 2a, Effingham got a combined 1-hitter, Carter Braddy hit a 3-run homer and Max Flack added a solo shot in the Hearts 4-3 win over Newton. Breese Central beat Father McGviney on their home field 10-4, Freeburg edged Columbia 4-3 at Nashville and at Vandalia, St Anthony shutout rival TTown 5-0.
- Massac County 1 Carterville 0 at Carterville
- Pinckneyville 5 Herrin 3 at DuQuoin
- Effingham 4 Newton 3 at Effingham
- Marquette 6 Gillespie 4 at Gillespie
- Breese Central 10 Father McGivney 4 at Glen Carbon
- Harrisburg 6 West Frankfort 4 at Harrisburg
- Roxana 6 Litchfield 5 at Litchfield
- Benton 13 Carmi 3 at Mt Carmel
- Freeburg 4 Columbia 3 at Nashville
- Tri Valley 9 Pana 5 at Pana
- St Anthony 5 TTown 0 at Vandalia
In 3a, Mascoutah beat Mt Vernon 4-0 to win their own regional, Triad over Jerseyville at Jersey 9-0.
- Triad 9 Jersey 0 at Jerseyville
- Waterloo 8 Marion 6 at Marion
- Mascoutah 4 Mt Vernon 0 at Mascoutah
- Jacksonville 8 Highland 2 at Mattoon
In 4a, O’Fallon won at Belleville East beating Belleville West 5-4 and Edwardsville defended their home field beating Collinsville 7-0.
