In 1a, Carlyle hosts Gibault, North Clay welcomes Casey, Sparta and Waltonville play from Wayne City.
- Cumberland v. WSS at Altamont
- Gibault at Carlyle
- Goreville v. Galatia at Cobden
- NCOE v. Crab Orchard at Gallatin County
- Casey at North Clay
- Arthur at Neoga
- Maryville Christian at New Athens
- Edwards County v. Trico at Steeleville
- Okaw Valley at Tuscola
- Sparta v. Waltonville at Wayne City
In 2a, Effingham hosts Newton, Breese Central plays the hosts at Father McGivney, Freeburg and Columbia play at Nashville and at Vandalia TTown takes on rival St Anthony.
- Massac County at Carterville
- Herrin v. Pinckneyville at DuQuoin
- Newton at Effingham
- Marquette at Gillespie
- Breese Central at Father McGivney
- West Frankfort at Harrisburg
- Roxana at Litchfield
- Carmi v. Benton at Mt Carmel
- Freeburg v. Columbia at Nashville
- Tri Valley at Pana
- TTown v. St Anthony at Vandalia
In 3a, Marion hosts Waterloo, Mt Vernon takes on the hosts at Mascoutah.
- Triad at Jerseyville
- Waterloo at Marion
- Mt Vernon at Mascoutah
- Jacksonville v. Highland at Mattoon
In 4a, Belleville West takes on O’Fallon at East while Edwardsville hosts Collinsville.
